SigmaER
SigmaER is a term used in some contexts to denote a putative endoplasmic reticulum–associated regulator presumed to mediate signaling between the endoplasmic reticulum (ER) and cytosolic transcriptional machinery. It is not established as a single, defined gene or protein in standard model organisms, and there is no consensus on its molecular identity.
Descriptions of sigmaER vary. In some speculative models, sigmaER is envisioned as an ER-membrane–embedded complex that
Evidence for sigmaER remains limited and contested. A small number of studies have reported sigmaER-like activity
If established, sigmaER would potentially link ER stress responses with transcriptional or metabolic regulation, contributing to
Related topics include sigma-1 receptor signaling, ER stress and the unfolded protein response, calcium handling by