Setinemine

Setinemine is a synthetic organic compound first reported in the early 2010s. Its molecular formula is C16H22N2O4 and it belongs to the class of modified amino acid derivatives frequently used in biochemical research. The molecule contains a bicyclic core derived from a pyrrolidine ring fused to a pyrimidinone scaffold. Chemical synthesis typically proceeds through a multi‑step route that begins with the reductive amination of a substituted pyrimidine with L‑glycine, followed by cyclization with diethyl carbonate and final protection‑deprotection steps to yield the free base.

Pharmacologically, Setinemine functions as a selective inhibitor of the serine protease elastase. In vitro studies have shown that it reduces enzymatic activity by more than 80 % at micromolar concentrations, making it a candidate for anti‑inflammatory drug development. Additionally, Setinemine has been investigated as a molecular probe for imaging studies, where it is conjugated to fluorophores to track protease expression in living cells.

In the laboratory, Setinemine is handled under standard safety protocols for small molecules. It is slightly toxic if ingested and may cause irritation to skin and eyes; therefore, materials safety data sheets recommend the use of gloves, goggles, and a fume hood. The compound is classified as a potential environmental hazard due to its persistence in aqueous solutions.

Regulatory status varies by jurisdiction. In the United States it is not listed as a controlled substance and is available to researchers under the Federal Food, Drug, and Cosmetic Act for investigational purposes. In the European Union, it is subject to the General Be it equivalent to a Schedule IV analogue, requiring a safety assessment for commercial distribution.