Sec6263komplexet

Sec6263komplexet is a proposed multiprotein complex described in some eukaryotic cell systems as part of the endoplasmic reticulum protein translocation machinery. The name signals its proposed association with the Sec62 and Sec63 components of the ER translocon, extending beyond the canonical Sec61-Sec62-Sec63 core. In the literature, Sec6263komplexet is treated as a potential module rather than a universally defined complex, and its status is the subject of ongoing research and debate.

Core components identified in affinity purification and mass spectrometry include Sec62 and Sec63, with a varying set of co-purifying proteins that appears to depend on species and cell context. The precise subunit composition, stoichiometry, and structural arrangement remain unresolved. Structural data are sparse; some groups have pursued cryo-electron microscopy, but consensus on architecture has not emerged.

Functionally, Sec6263komplexet is thought to participate in the targeting and possibly translocation of secretory and membrane proteins at the ER, potentially coordinating with the Sec61 channel and influencing folding quality control and stress signaling. Observed phenotypes upon perturbation are context-dependent, and there is no broad agreement on essentiality or disease relevance across organisms.

The term is not universally used; it appears mainly in discussions of an extended Sec62-Sec63 network. Many researchers view it as a functional module rather than a fixed complex, with definitions likely to evolve as new data emerge.