SdiAmediated

SdiAmediated regulation refers to regulatory effects governed by the transcriptional regulator SdiA in certain bacteria, notably Escherichia coli and Salmonella enterica. SdiA belongs to the LuxR family of quorum-sensing regulators and responds to signaling molecules produced by other bacterial species rather than by the host organism.

Unlike canonical quorum-sensing regulators that synthesize their own signals, SdiA is not an endogenous producer of acyl-homoserine lactones (AHLs) in these cells. Instead, it senses exogenous AHLs that diffuse into the cell from neighboring bacteria and modulates gene expression in response to these cues.

Activation or repression of SdiA affects a set of genes involved in surface structures, motility, and stress responses, and can influence virulence-related traits in pathogenic strains. The specific gene targets and outcomes vary with the bacterial strain, environmental conditions, and the particular AHLs detected.

Its function highlights interspecies communication in polymicrobial environments and can shape fitness, colonization, and pathogenic potential by allowing bacteria to adjust behavior in the presence of other species.

Research on SdiA-mediated regulation focuses on understanding how exogenous quorum-sensing signals are integrated into bacterial transcriptional programs and how this cross-talk influences host interactions and disease dynamics.