SdiAmediated
SdiAmediated regulation refers to regulatory effects governed by the transcriptional regulator SdiA in certain bacteria, notably Escherichia coli and Salmonella enterica. SdiA belongs to the LuxR family of quorum-sensing regulators and responds to signaling molecules produced by other bacterial species rather than by the host organism.
Unlike canonical quorum-sensing regulators that synthesize their own signals, SdiA is not an endogenous producer of
Activation or repression of SdiA affects a set of genes involved in surface structures, motility, and stress
Its function highlights interspecies communication in polymicrobial environments and can shape fitness, colonization, and pathogenic potential
Research on SdiA-mediated regulation focuses on understanding how exogenous quorum-sensing signals are integrated into bacterial transcriptional