SctK
SctK is a conserved protein component of bacterial type III secretion systems (T3SS), a syringe-like apparatus used by many Gram-negative pathogens to inject effector proteins into host cells. The SctK protein is typically encoded within T3SS gene clusters, and orthologs are known in several species where it is designated as YscK in Yersinia or PscK in Pseudomonas.
In the cytoplasm, SctK is part of the sorting platform that sits at the cytoplasmic face of
Expression of sctK is coordinated with other T3SS genes and is often regulated by environmental cues and
SctK exemplifies the diversity and conservation of the T3SS core components, reflecting a modular architecture that