Schweißtest

The Schweißtest, also known as the sweat test or pilocarpine iontophoresis test, is a diagnostic procedure used primarily to measure the concentration of chloride in sweat. This test is essential for diagnosing cystic fibrosis (CF), a genetic disorder that affects the lungs and digestive system by causing the body to produce abnormally thick and sticky mucus.

During the procedure, a mild electric current is applied to the skin to stimulate sweat glands, allowing sweat to be collected. Pilocarpine, a medication that increases sweating, is often used to enhance the test’s accuracy. The collected sweat is then analyzed to determine chloride levels. Elevated chloride concentrations in sweat are indicative of cystic fibrosis, as individuals with the condition often have defective chloride transport channels in their sweat ducts.

The Schweißtest is typically performed on infants and young children, as cystic fibrosis can be detected early through newborn screening programs. It is considered a safe and non-invasive method, though some patients may experience minor discomfort or skin irritation from the electrical stimulation or pilocarpine application. The test is highly reliable when conducted by trained medical professionals in a clinical setting.

In addition to diagnosing cystic fibrosis, the Schweißtest can also be used to monitor disease progression or response to treatment in confirmed cases. While not a definitive standalone test, it is often combined with genetic testing or clinical assessments for a comprehensive diagnosis. The procedure is widely recognized as a standard diagnostic tool in pediatric and genetic medicine.