Saytzeffs
Saytzeffs, also known as Saytzeff's rule or Zaitsev's rule, is an empirical rule in organic chemistry that describes the regioselectivity of elimination reactions. It states that in an elimination reaction, the more substituted alkene is typically the major product. The substitution refers to the number of carbon atoms directly attached to the carbons involved in the double bond. For example, if an elimination reaction can produce both a disubstituted alkene and a monosubstituted alkene, Saytzeff's rule predicts that the disubstituted alkene will be formed in greater yield. This is generally attributed to the greater thermodynamic stability of more substituted alkenes.
Saytzeff's rule is most commonly applied to E1 and E2 elimination reactions. In E1 reactions, where a
The rule was named after the Russian chemist Aleksandr Butlerov, who first described the principle, and later