Salicyluric
Salicyluric acid, often referred to as salicyluric, is the glycine conjugate of salicylic acid and a major urinary metabolite of salicylates in humans. It is formed in the liver through a phase II metabolism reaction in which salicylic acid is conjugated with glycine, producing salicyluric acid, which is subsequently excreted in the urine. This glycine conjugation pathway is a primary route by which the body eliminates salicylate after ingestion of aspirin or other salicylates. Other minor urinary metabolites of salicylates can include free salicylate and various glucuronide conjugates.
In clinical toxicology, urinary salicyluric acid serves as a biomarker of salicylate exposure. Measuring its concentration
Salicyluric acid can be detected and quantified using analytical techniques such as high-performance liquid chromatography or