SUNdomain
The SUN domain refers to a conserved protein domain found in the SUN family of inner nuclear membrane proteins. The name derives from the first proteins in which it was identified, Sad1 and UNC-84, and the domain is typically located toward the C-terminus of SUN proteins. The SUN domain is involved in interaction with KASH family proteins in the perinuclear space, forming a bridge across the nuclear envelope.
In cells, SUN-domain proteins are components of the linker of nucleoskeleton and cytoskeleton (LINC) complex, which
The SUN domain is widely conserved across eukaryotes and is found in diverse organisms, including fungi, plants,
Research on SUN-domain proteins encompasses structural biology, cell biology, and developmental biology. Studies typically focus on