STK11Mutation
STK11 mutation refers to alterations in the STK11 gene, which encodes the serine/threonine kinase 11 enzyme, also known as LKB1. STK11 functions as a tumor suppressor and is a central regulator of cellular energy homeostasis and metabolism through activation of the AMPK family of kinases. Mutations can disrupt these pathways and contribute to tumor development.
Germline STK11 mutations cause Peutz-Jeghers syndrome, an inherited disorder characterized by mucocutaneous pigmentation and hamartomatous polyps
The loss of STK11/LKB1 function impairs the energy-sensing AMPK pathway, leading to unchecked anabolic growth, altered
Clinical significance varies by cancer type. In non-small cell lung cancer, STK11 mutations are associated with
Diagnosis is typically through DNA sequencing of tumor tissue to detect somatic mutations, with germline testing