SRPribosoomnascent
SRPribosoomnascent is a term used in cell biology to describe the ribosome-nascent chain complex bound by the signal recognition particle during the co-translational targeting of secretory and membrane proteins. It denotes the transient assembly formed when a nascent polypeptide bearing a signal sequence emerges from the ribosome and is captured by SRP to direct the translating ribosome to a membrane destination.
The signal recognition particle is a ribonucleoprotein that recognizes signal sequences and temporarily halts translation. In
Mechanistically, SRP binds the emerging signal sequence and pauses elongation, guiding the ribosome to the SRP
SRPribosoomnascent is central to co-translational protein sorting, ensuring correct targeting and reducing cytosolic misfolding. Disruption of