SN38pitoisuudet
SN38pitoisuudet refers to the concentrations of SN38, the active metabolite of irinotecan, in the body. Irinotecan is a chemotherapy drug used to treat various cancers, particularly colorectal cancer. After administration, irinotecan is converted in the liver by the enzyme carboxylesterase 2 (CES2) into SN38. SN38 is significantly more potent than irinotecan as an inhibitor of topoisomerase I, an enzyme crucial for DNA replication and repair.
The concentration of SN38 in the plasma and at the tumor site is a key determinant of
Factors influencing SN38pitoisuudet include genetic variations in genes involved in irinotecan metabolism, such as CES2 and