SLC30A6

SLC30A6 is a human gene that encodes a member of the ZnT (SLC30) family of zinc transporters. The protein produced by SLC30A6 is commonly referred to as ZnT6 and is involved in regulating intracellular zinc levels by moving Zn2+ from the cytosol into intracellular compartments, particularly within the secretory pathway.

Structurally, ZnT6 is predicted to contain six transmembrane domains with cytosolic N- and C-termini. The protein is primarily localized to the Golgi apparatus and the trans-Golgi network, where it contributes to maintaining zinc homeostasis in the secretory pathway. In some cell types, ZnT6 may also associate with endosomal or lysosomal compartments, reflecting a broader role in intracellular zinc handling.

Functionally, ZnT6 acts as a zinc transporter that exchanges zinc for protons across membranes, effectively sequestering Zn2+ into the Golgi lumen. By regulating zinc availability in the secretory pathway, ZnT6 influences the maturation and activity of zinc-dependent enzymes and the processing and trafficking of zinc-containing proteins.

Expression of SLC30A6 is widespread across tissues, with variation in levels between different cell types. Its activity supports proper protein processing and enzyme maturation within the secretory pathway, contributing to cellular zinc homeostasis and broader physiological zinc balance.

In humans, SLC30A6 is conserved across vertebrates, reflecting its role in zinc transport and intracellular metal ion regulation. While alterations in expression have been investigated in various contexts, there is no widely established disease phenotype directly linked to SLC30A6 mutations, and research continues to clarify its specific physiological and potential clinical roles.