SLC30A6
SLC30A6 is a human gene that encodes a member of the ZnT (SLC30) family of zinc transporters. The protein produced by SLC30A6 is commonly referred to as ZnT6 and is involved in regulating intracellular zinc levels by moving Zn2+ from the cytosol into intracellular compartments, particularly within the secretory pathway.
Structurally, ZnT6 is predicted to contain six transmembrane domains with cytosolic N- and C-termini. The protein
Functionally, ZnT6 acts as a zinc transporter that exchanges zinc for protons across membranes, effectively sequestering
Expression of SLC30A6 is widespread across tissues, with variation in levels between different cell types. Its
In humans, SLC30A6 is conserved across vertebrates, reflecting its role in zinc transport and intracellular metal