SHBGn

SHBGn, or sex hormone-binding globulin non-specific, is a protein found in the blood that binds to sex hormones, particularly testosterone and estrogen. It plays a crucial role in the regulation of hormone levels in the body. SHBGn is produced by the liver and is a component of the sex hormone-binding globulin (SHBG) family, which also includes SHBG-specific (SHBGs) and SHBG-like proteins (SHBGl).

The primary function of SHBGn is to transport sex hormones in the bloodstream, preventing them from binding to hormone receptors and exerting their effects. This transport function helps maintain the balance of hormone levels in the body. SHBGn also acts as a buffer, protecting tissues from excessive hormone exposure.

SHBGn levels can be influenced by various factors, including age, sex, and certain medical conditions. For example, SHBGn levels tend to increase with age in both men and women, which can contribute to a decrease in free testosterone and estrogen levels. In men, SHBGn levels can also be elevated in conditions such as liver disease and obesity.

SHBGn is typically measured in clinical settings to assess hormone levels and diagnose hormonal imbalances. However, it is important to note that SHBGn is not specific to any particular hormone and can bind to both testosterone and estrogen. Therefore, changes in SHBGn levels may not always indicate a specific hormonal issue.

In summary, SHBGn is a protein that plays a vital role in the regulation of sex hormone levels in the body. Its levels can be influenced by various factors, and it is often measured in clinical settings to assess hormone balance. However, its non-specific binding to hormones means that changes in SHBGn levels may not always indicate a specific hormonal issue.