SECISStruktur
SECISStruktur, or selenocysteine insertion sequence structure, refers to an RNA secondary structure that enables the incorporation of selenocysteine at UGA codons during translation. It is a key element in the biosynthesis of selenoproteins, proteins that contain the amino acid selenocysteine and often participate in redox biology and antioxidant defense.
The SECIS element is located in the messenger RNA downstream of the UGA codon that is to
SECIS elements recruit dedicated protein and tRNA components to enable insertion of selenocysteine. In bacteria, the
SECIS elements vary in sequence and length across domains and among individual genes, but share the core
Proper SECIS function is essential for the expression of selenoproteins. Disruption of SECIS integrity or its