SCN1ASCN11A

SCN1ASCN11A is not an established gene symbol in major human gene nomenclature databases. It appears to be a concatenation of two distinct voltage-gated sodium channel alpha subunit genes, SCN1A and SCN11A, which encode Nav1.1 and Nav1.9, respectively. In current genomics literature, the two genes are treated separately, with distinct tissue expression patterns and disease associations.

SCN1A encodes the alpha subunit of the voltage-gated sodium channel Nav1.1. It contributes to the generation and propagation of action potentials in neurons, with prominent expression in cortical and hippocampal interneurons. Mutations in SCN1A are linked to epileptic disorders, notably Dravet syndrome (severe early-onset epilepsy) and generalized epilepsy with febrile seizures plus (GEFS+). Phenotypes range from febrile seizures to severe, intractable epilepsy. Management includes tailored antiepileptic therapy; sodium channel blockers can worsen seizures in some SCN1A-related conditions.

SCN11A encodes Nav1.9, a sodium channel expressed in peripheral sensory neurons, contributing to nociceptor excitability and pain signaling. Rare variants in SCN11A have been associated with pain disorders and altered nociception; however, the clinical significance is an active area of research, and genotype–phenotype relationships are still being defined.

Because SCN1A and SCN11A are separate genes, the combined symbol SCN1ASCN11A does not reflect a single, recognized locus. If encountered, it most likely represents a search artifact, a fusion construct in a research dataset, or a shorthand used in a project-specific context. For authoritative information, refer to official entries in resources such as HGNC or NCBI Gene, which list SCN1A and SCN11A separately.