Retrosyntetisk
Retrosynthetic analysis, often abbreviated as retrosynthesis, is a fundamental concept in organic chemistry, particularly in the design of synthetic routes for complex molecules. The term "retrosynthesis" was coined by E.J. Corey, who received the Nobel Prize in Chemistry in 1990 for his contributions to the development of this method. Retrosynthesis involves working backwards from the desired target molecule to simpler precursors, breaking down the synthesis into more manageable steps. This approach allows chemists to plan the synthesis more effectively, ensuring that each step is feasible and that the overall synthesis is efficient.
The process of retrosynthesis typically begins with the target molecule and involves repeatedly applying disconnections, which
One of the key advantages of retrosynthesis is its ability to simplify the planning of complex syntheses.
Retrosynthetic analysis is not limited to the synthesis of organic molecules. It can also be applied to