Regiospecific
Regiospecific describes a chemical reaction that proceeds with high selectivity for forming a product at a particular position in the substrate, leading to a single regioisomer. In a regiospecific process, bond formation occurs predominantly at one site, and alternative regioisomeric products are formed only in minor amounts or not at all. This is a stricter notion than regioselectivity, which describes preference among possible regioisomers but does not imply exclusive formation.
Regiospecificity is influenced by factors such as substrate substitution patterns, directing groups, reaction mechanism, catalysts, solvents,
Examples illustrate common regiospecific outcomes. The acid-catalyzed addition of hydrogen bromide to propene under standard conditions
Applications of regiospecificity are important in organic synthesis and medicinal chemistry, where the position of new