Reactome

Reactome is a freely accessible, open-source database and pathway analysis resource that provides detailed information on biological pathways and processes. Developed and maintained by the Institute of Systems Biology at the University of Edinburgh and other collaborating institutions, Reactome aims to map the molecular mechanisms underlying cellular functions in humans and other organisms. The platform serves as a comprehensive resource for researchers in systems biology, bioinformatics, and biomedical research.

Reactome covers a wide spectrum of biological pathways, including signal transduction, metabolism, gene expression, cell cycle, and immune responses. It organizes pathways hierarchically, allowing users to explore detailed reactions or broader biological functions. Each pathway entry includes information about participating molecules, interactions, and biochemical reactions, with supporting references and evidence annotations.

Data within Reactome is curated manually by scientific experts, ensuring high accuracy and reliability. The database integrates data from various sources, including experimental results, literature, and other pathway repositories, to provide a robust and coherent map of biological processes. In addition to the pathway data, Reactome offers tools for pathway enrichment analysis, visualization, and data integration, aiding researchers in interpreting high-throughput biological data.

Reactome is accessible through a user-friendly web interface, APIs, and downloadable datasets. Its open data policy allows broad use for academic, clinical, and industrial research, supporting advancements in understanding disease mechanisms, drug discovery, and personalized medicine. The platform continuously updates its content, expanding coverage to include emerging pathways and integrating new scientific insights.

Overall, Reactome is a vital resource for translating complex biological data into meaningful insights, fostering a systems-level understanding of molecular biology.