RNAdriven

RNAdriven is a term used to describe a conceptual framework in biotechnology and information science that centers on RNA as the primary driver of regulation and computation. In biology, RNAdriven denotes systems in which RNA molecules perform regulatory and sensing roles that control gene expression and cellular behavior. This includes riboregulators that modulate transcription or translation in response to inputs, RNA sensors that detect ligands, and RNA devices that implement logic operations within cells. In computing and nanotechnology, RNAdriven design refers to using RNA-based components to implement decision rules, data processing, or programmable actuation in molecular devices, sometimes in conjunction with DNA and proteins.

Origins and usage: The term emerged in interdisciplinary discussions in the 2010s and 2020s, particularly among researchers in synthetic biology, RNA biology, and bioengineering. It is not a formally standardized field name but appears as a descriptive umbrella in articles and product literature to distinguish RNA-centric regulatory strategies from DNA- or protein-centric approaches.

Applications: Potential applications include programmable therapeutics using RNA switches to regulate gene therapy; biosensors that transduce molecular signals into RNA-based outputs; metabolic control using RNA regulators to balance pathways; and RNA-based nanodevices for diagnostics or environmental sensing. In computing contexts, RNAdriven concepts inform the design of RNA-based logic circuits and programmable materials.

Challenges and outlook: Major challenges include stability of RNA in biological environments, delivery, off-target regulation, and the complexity of designing robust RNA circuits. Advances in RNA design algorithms, chemical modifications, and delivery methods are expanding the practical use of RNAdriven approaches.