RNAbound

RNAbound is an open-access database designed to catalog and analyze RNA-binding proteins (RBPs) and their interactions with RNA molecules. Developed as a resource for the scientific community, it provides comprehensive information on the binding sites, motifs, and functional roles of RBPs across various organisms, primarily humans. The database integrates experimental data from high-throughput sequencing techniques such as CLIP (CrossLinking and Immunoprecipitation), PAR-CLIP, and iCLIP, alongside computational predictions to map RNA-binding events with high precision.

RNAbound organizes its data into structured entries, detailing the binding preferences of individual RBPs, including their sequence-specific motifs and structural features. Users can explore interactions at the nucleotide resolution level, enabling detailed studies of post-transcriptional regulation, alternative splicing, and other RNA-mediated processes. The database also includes annotations on the functional consequences of these interactions, such as effects on mRNA stability, translation efficiency, and gene expression regulation.

Accessible via a user-friendly web interface, RNAbound allows researchers to query specific RBPs, visualize binding sites on RNA transcripts, and download datasets for further analysis. It supports cross-referencing with other genomic and proteomic databases, facilitating multi-omics integration. The platform is regularly updated with new experimental data and computational refinements to ensure its relevance in advancing RNA biology research.

RNAbound serves as a valuable tool for experimental biologists, computational researchers, and clinicians studying RNA-related diseases, such as cancer, neurodegenerative disorders, and metabolic syndromes. By providing a centralized repository of RNA-binding information, it accelerates discoveries in gene regulation and therapeutic targeting. The database is freely available under an open-access model, promoting collaborative research and innovation in the field.