RING2s

RING2, also known as RNF132, is a protein encoded by the RNF132 gene in humans. It is a member of the Ring finger protein family, characterized by the presence of a RING domain, a zinc-finger motif involved in protein-protein interactions and E3 ubiquitin ligase activity. RING2 functions as an E3 ubiquitin ligase, playing a role in the ubiquitination of target proteins. This post-translational modification can alter the function, localization, or stability of the modified protein, thus influencing various cellular processes.

Research suggests that RING2 is involved in regulating gene expression and cell differentiation. It has been implicated in pathways related to oncogenesis and tumor suppression, with its aberrant expression potentially contributing to the development of certain cancers. Studies have also indicated a role for RING2 in DNA repair mechanisms and cellular responses to stress. The precise molecular mechanisms and the full spectrum of its biological functions are still areas of ongoing investigation. Understanding the activity of RING2 is crucial for deciphering its involvement in normal cellular homeostasis and its potential as a therapeutic target in disease.