RNF132

RNF132, also known as RNF132-AS1, is a long non-coding RNA (lncRNA) located on chromosome 17. Its primary function is not fully elucidated, but research suggests it plays a role in gene regulation. It is transcribed from the opposite strand of the Ring finger protein 132 (RNF132) gene, which encodes a ubiquitin ligase. This genomic arrangement indicates a potential for cis-regulation, where RNF132-AS1 might influence the expression of the neighboring RNF132 gene.

Studies have indicated that RNF132-AS1 expression can be altered in various cellular contexts. For instance, it has been observed to be differentially expressed in certain types of cancer, hinting at a possible involvement in tumorigenesis or tumor progression. The precise mechanisms by which RNF132-AS1 exerts its regulatory effects are still under investigation. Potential mechanisms include acting as a scaffold for protein complexes, interacting with chromatin-modifying enzymes, or sequestering microRNAs. Further research is needed to fully understand its biological significance and potential therapeutic implications.