cisregulation
Cisregulation refers to the regulation of a gene's expression by DNA sequences that are on the same molecule of DNA as the gene they control. This contrasts with trans-regulatory regulation, where diffusible factors such as transcription factors or RNAs, encoded elsewhere in the genome, affect gene expression.
Cis-regulatory elements include promoters, enhancers, silencers, insulators, and untranslated region sequences. Promoters are typically located near
In bacteria, cis-regulation often involves promoters, operators, and riboswitches that respond to environmental cues. In eukaryotes,
Mutations in cis-regulatory elements can alter when, where, and how much a gene is expressed, contributing to