RASA3

RASA3, also known as Ras-related protein RASA3, is a protein that in humans is encoded by the RASA3 gene. The RASA3 gene is located on chromosome 12. This gene encodes a protein that belongs to the RASA family of GTPase-activating proteins (GAPs). These GAPs are negative regulators of the Ras superfamily of small GTPases. Specifically, RASA3 acts as a GAP for RHOA, a member of the Rho family of GTPases.

The protein RASA3 plays a crucial role in regulating cell proliferation, differentiation, and survival. Its interaction with RHOA influences various cellular processes, including cytoskeletal organization, cell motility, and membrane trafficking. Dysregulation of RASA3 has been implicated in several diseases, including certain types of cancer and developmental disorders. Research into RASA3's precise functions and its involvement in disease pathogenesis is ongoing, aiming to understand its potential as a therapeutic target. The RASA3 protein contains a conserved catalytic domain responsible for its GAP activity and other regulatory domains that mediate its interaction with other proteins and cellular components. Understanding the molecular mechanisms by which RASA3 controls RHOA signaling is a key area of investigation in cell biology and disease research.