RAP74
RAP74, also known as the 74-kilodalton subunit of transcription factor IIF (TFIIF), is a protein that in humans is encoded by the GTF2F2 gene and is conserved across many eukaryotes. It forms a functional heterodimer with the RAP30 subunit (GTF2F1) to comprise the TFIIF complex that associates with RNA polymerase II.
In transcription initiation, TFIIF plays a role in promoter recognition and assembly of the preinitiation complex.
RAP74 is a nuclear protein with a molecular weight of approximately 74 kDa. Its structure includes regions
Evolutionarily, RAP74/GTF2F2 is maintained across diverse species, reflecting a fundamental role in gene expression. In humans,
Overall, RAP74 is a core component of the transcription initiation apparatus, enabling efficient recruitment and stabilization