Q315IQR

Q315IQR is a mutation notation that appears in genetic and protein sequence reports. It typically denotes a missense change at amino acid position 315, where the original residue glutamine (Q) is substituted by isoleucine (I). The trailing letters “QR” are not part of standard mutation nomenclature and their meaning is context-dependent; they may refer to a nearby sequence context, a second mutation in the same protein, a specific dataset tag, or another annotation used by a particular study or database. Because “Q315IQR” is not a universally standardized identifier, its exact interpretation can vary between sources.

In general, notation of this form is used to describe protein variants at the level of amino acid sequence rather than DNA sequence. The significance of a Q315I substitution depends on the protein in which it occurs. If position 315 lies within a functional domain or near a catalytic site, the mutation can influence protein activity, stability, binding interactions, or regulatory control. Determining the effect typically requires experimental evidence, such as enzymatic assays, structural studies, or cellular models, rather than predictions alone.

Context is essential to interpret Q315IQR correctly. Researchers and clinicians rely on the specific gene, protein, and study design to assess whether the substitution has pathogenic, neutral, or context-dependent effects. For precise interpretation, consult the primary source or database entry associated with the protein of interest and verify what the “QR” component denotes in that context.