ProteinCoupled
Proteincoupled is a descriptor used in biochemistry and cell biology to denote systems in which proteins mediate the coupling of one event to another, such as signal initiation to cellular response, or the linkage of energy transduction to function. In most biological contexts, protein coupling involves physical interactions that transfer information from one protein to another, often triggered by ligand binding or post-translational modification. The interactions are typically mediated by defined protein domains and can be modulated by cellular context, localization, and expression levels.
A central example is protein-coupled receptors (GPCRs), where binding of an extracellular ligand induces a conformational