PolypyrimidinTrakt
PolypyrimidinTrakt is a term used in molecular biology to describe the polypyrimidine tract, a region within pre-mRNA introns that is rich in pyrimidine nucleotides, primarily cytosine and uracil. This tract is typically located upstream of the 3' splice site and plays a key role in the recognition of splice junctions during the early stages of spliceosome assembly.
The polypyrimidine tract serves as a binding platform for splicing factors, most notably the U2 auxiliary factor
PolypyrimidinTrakt characteristics vary among introns and species. Longer or more pyrimidine-rich tracts generally enhance 3' splice
Researchers identify polypyrimidinTrakte through sequence analysis and comparative genomics, often supplemented by experimental assays such as