PI3KAkttie
PI3KAkttie is a term that appears in a small number of discussions to describe a proposed regulatory factor at the intersection of phosphoinositide 3-kinase (PI3K) and AKT signaling. The name combines elements of the PI3K-AKT pathway with an inferred adaptor or scaffold function, but it is not an established protein name, and there is no broad consensus on its existence, structure, or role.
In speculative models, PI3KAkttie would function as a scaffold or adaptor that helps coordinate AKT activation
Potential interaction partners include PI3K subunits (such as p85 and p110), PDK1, mTORC2, AKT itself, PTEN, SHIP
Clinical relevance remains hypothetical; dysregulation of the PI3K-AKT axis is widely implicated in cancer and metabolic
See also: PI3K-AKT signaling pathway, adaptor proteins, scaffold proteins, signal transduction.