Octenidin

Octenidine dihydrochloride, commonly marketed as Octenisept among other preparations, is a topical antiseptic used for disinfection of skin and mucous membranes. It is a cationic antiseptic that acts by interacting with and disrupting microbial cell membranes, producing rapid bactericidal effects.

formulations and indications

Octenidine is usually used in ready-to-use solutions that combine octenidine dihydrochloride with phenoxyethanol. These products are employed for wound cleansing, treatment of minor skin injuries, and antisepsis of mucous membranes prior to procedures. They are also used for preoperative skin disinfection and for routine cleansing of skin and mucosa in clinical and home settings. Octenidine-containing products are intended for topical use only and are not designed for systemic administration.

antimicrobial activity

In vitro, octenidine dihydrochloride shows broad-spectrum activity against many common skin pathogens, including Gram-positive bacteria, many Gram-negative bacteria, and yeasts. It is valued for rapid onset of action and relatively low potential for resistance development. The activity can vary with formulation and concentration, and products often optimize effectiveness for specific clinical applications.

safety and precautions

Octenidine products are generally well tolerated on intact skin and mucous membranes, but can cause irritation or allergic reactions in sensitive individuals. Eyes should be protected from contact. In case of accidental exposure or persistent irritation, use should be discontinued and medical advice sought. As with any antiseptic, octenidine should be used according to manufacturer instructions and local guidelines.

regulatory status

Octenidine dihydrochloride-containing products are widely used in many European countries and elsewhere, but regulatory approval and specific indications vary by region. They are not universally approved for all markets, and healthcare providers reference local regulatory guidance when selecting antiseptic agents.