Notoginsenoside

Notoginsenoside is a group of saponins found in plants of the Panax genus, most notably in Panax notoginseng, also known as Sanqi or Tianqi. These compounds are triterpenoid saponins, belonging to the dammarane class. Their chemical structures are characterized by a tetracyclic dammarane skeleton with various glycoside side chains. Several specific notoginsenosides have been identified, with notoginsenoside R1, R2, R3, and R4 being among the most well-studied.

Traditional Chinese Medicine has utilized Panax notoginseng for centuries, with notoginsenosides being considered the primary active constituents responsible for its therapeutic effects. These effects are often attributed to their potential hemostatic, anti-inflammatory, analgesic, and cardiovascular protective properties. Research has explored their mechanisms of action, suggesting roles in regulating blood coagulation, inhibiting inflammatory pathways, and protecting against oxidative stress.

Modern scientific investigations have focused on isolating and characterizing these compounds, as well as evaluating their pharmacological activities in preclinical studies. While promising, further rigorous clinical trials are needed to definitively establish their efficacy and safety in human medicine. The extraction and purification of notoginsenosides from plant sources are also areas of ongoing research to optimize yield and purity.