Notch14

Notch14 is not a standard or universally recognized gene symbol in human biology. In vertebrates, the four canonical Notch receptors are designated NOTCH1 through NOTCH4. The term Notch14 sometimes appears in literature as informal shorthand for NOTCH4 or as a mislabeling of an additional Notch-like gene in certain non-mammalian species. However, there is no widely accepted evidence for a distinct, widely characterized receptor named Notch14 in humans.

As with other Notch receptors, a Notch14-like protein would be expected to be a single-pass transmembrane receptor featuring an extracellular domain with EGF-like repeats and an intracellular domain that can release a transcriptionally active NICD (Notch intracellular domain) after proteolytic processing. Activation typically occurs through ligands of the Delta-like or Jagged families, followed by gamma-secretase–mediated cleavage and translocation of NICD to the nucleus to regulate target genes via CSL/RBP-Jκ and co-activators such as Mastermind-like proteins.

Functions attributed to Notch signaling in general include regulation of cell fate decisions, differentiation, proliferation, and tissue homeostasis during development. NOTCH4, in particular, has been studied for roles in vascular development and angiogenesis, with effects that appear context- and species-dependent. The broader Notch pathway is implicated in various cancers, cardiovascular diseases, and developmental disorders, though disease associations are typically discussed in the context of NOTCH1–NOTCH4 rather than a separate Notch14 receptor.

Conclusion: Notch14 remains a nonstandard term; for precise information, it is preferable to refer to NOTCH4 or to consult species- or database-specific nomenclature.