Nidogeni

Nidogeni is a protein that plays a crucial role in the development and maintenance of various tissues in the human body. It is a member of the nidogen family, which includes nidogen-1 and nidogen-2. Nidogeni is primarily found in the extracellular matrix, where it interacts with other proteins to form a stable network that provides structural support and regulates cellular behavior.

The gene encoding nidogeni is located on chromosome 12 in humans. Mutations in this gene have been associated with several genetic disorders, including Ehlers-Danlos syndrome type VIIC (EDS-VIIC) and mucopolysaccharidosis type VII (MPS-VII). These disorders are characterized by connective tissue abnormalities, joint hypermobility, and intellectual disability.

Nidogeni is involved in various biological processes, including cell adhesion, migration, and differentiation. It interacts with other extracellular matrix proteins, such as collagen and laminin, to form a complex network that supports tissue integrity and function. Nidogeni also plays a role in the regulation of cell signaling pathways, which are essential for normal cellular behavior.

In summary, nidogeni is a protein that is essential for the development and maintenance of various tissues in the human body. Mutations in the gene encoding nidogeni can lead to genetic disorders characterized by connective tissue abnormalities and intellectual disability. Nidogeni interacts with other extracellular matrix proteins to form a stable network that provides structural support and regulates cellular behavior.