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Ngn1

Neurogenin-1 (Ngn1), also known as NEUROG1, is a basic helix-loop-helix (bHLH) transcription factor that acts as a proneural gene in vertebrate neurogenesis. It is encoded by the NEUROG1 gene and belongs to the neurogenin family, which also includes NEUROG2 and NEUROG3.

Function: Ngn1 promotes the differentiation of neural progenitor cells into neurons. It activates neuronal programs by

Expression and development: During vertebrate development, NEUROG1 is expressed in neural progenitors that give rise to

Regulation and significance: Ngn1 integrates signals from multiple pathways, including Notch, Wnt, and growth factors, to

Related topics include NEUROG2, NEUROG3, and Notch signaling.

binding
E-box
sequences
in
DNA
and
upregulating
downstream
targets
such
as
NEUROD1
and
other
neurogenic
genes.
Ngn1
often
operates
in
a
cascade
with
other
proneural
factors
and
interacts
with
Notch
signaling
to
regulate
the
balance
between
progenitor
maintenance
and
neuronal
differentiation
through
lateral
inhibition.
neurons
in
regions
of
the
central
and
peripheral
nervous
system,
including
the
hindbrain
and
spinal
cord,
and
in
cranial
sensory
ganglia.
Loss-of-function
studies
in
mice
show
reduced
production
of
certain
neuronal
populations,
underscoring
its
role
in
specific
lineage
decisions.
time
and
pattern
neurogenesis.
Beyond
development,
NEUROG1
has
been
explored
in
laboratory
settings
for
reprogramming
non-neuronal
cells
toward
a
neuronal
fate,
contributing
to
cell-based
models
of
neurogenesis
and
regenerative
research.