NeuroD
NeuroD is a family of vertebrate basic helix-loop-helix transcription factors that regulate neuronal differentiation and pancreatic development. Members include NEUROD1, NEUROD2, NEUROD4, and NEUROD6; the term NeuroD is often used to refer specifically to NEUROD1. These proteins function as transcription factors that bind E-box sequences as heterodimers with E-proteins, such as E12/E47, to control the expression of genes involved in differentiation, maturation, and cell survival.
In development, NeuroD factors promote neuronal differentiation and maturation and contribute to the formation of specific
Regulation of NeuroD activity involves interactions with other proneural factors and signaling pathways. NeuroD proteins often
Clinical relevance: Mutations in NEUROD1 have been linked to a monogenic form of diabetes (MODY6) and may