Nearsinglemolecule
Nearsinglemolecule is a term used in scientific literature, particularly in the fields of analytical chemistry and spectroscopy, to describe experiments or phenomena that are close to, but not quite at, the single-molecule level. In these experiments, the number of molecules in the detection volume is very small, often ranging from a few to a few hundred, rather than the macroscopic quantities typically found in bulk measurements. This allows for the observation of statistical variations and heterogeneities that would be averaged out in traditional methods.
The techniques employed in nearsinglemolecule studies often involve highly sensitive detection methods, such as fluorescence microscopy,
Applications of nearsinglemolecule measurements can be found in various areas, including the study of protein folding