Nanoelectrospray
Nanoelectrospray is a form of electrospray ionization optimized for extremely low liquid flow rates and small-capillary emitters. It is used in mass spectrometry to generate gas-phase ions from liquid samples with high efficiency and sensitivity while minimizing sample consumption.
The technique relies on applying an electric field to a liquid at the tip of a narrow
Instrumentation typically includes a nanoelectrospray emitter, often a pulled glass capillary or a microfabricated device, connected
Advantages of nanoelectrospray include heightened sensitivity, lower sample consumption, and, in some cases, improved tolerance to
Applications span proteomics, especially for limited or precious samples, as well as metabolomics, lipidomics, and intact-protein