NOAELbased
NOAELbased refers to a methodology for determining safe exposure levels of substances, particularly in toxicology and risk assessment. NOAEL stands for No Observed Adverse Effect Level. The NOAEL is the highest dose of a substance administered in a study that causes no statistically or biologically significant adverse effects when compared to a control group.
The NOAELbased approach utilizes this identified NOAEL to derive acceptable exposure limits. This is typically achieved
For example, a regulatory agency might divide the NOAEL by a factor of 100 to account for