NADHubiquinone
NADHubiquinone is a term used in some discussions of redox biology to denote a hypothetical conjugate that combines features of nicotinamide adenine dinucleotide (NADH) and ubiquinone (coenzyme Q). It is not a standard metabolite in cellular metabolism, and as of now there is no widely accepted chemical entity with this name in the primary literature. The concept envisions a molecule bearing a hydrophilic NADH-like head that can participate in aqueous redox reactions and a hydrophobic ubiquinone-like tail that can reside within lipid membranes, creating a potential amphipathic redox mediator.
If realized, NADHubiquinone would hypothetically shuttle electrons between soluble enzyme systems and membrane-associated electron carriers. The
Synthesis would likely require protection-deprotection strategies to assemble a linkage that preserves the redox-active sites. Potential