NADHlike
NADHlike is a protein domain identified in a variety of bacterial, archaeal, and eukaryotic proteins that participate in electron transfer processes. The domain is typically 180–220 amino acids in length and is characterized by a Rossmann-like fold that binds nicotinamide adenine dinucleotide (NADH) or related reduced flavin cofactors. Conserved sequence motifs such as the GXGXXG glycine-rich loop near the N‑terminus and a catalytic glutamate or aspartate residue are often present, allowing the domain to act as an oxidoreductase or as a redox-sensitive regulatory module.
Members of the NADHlike family have been found in dehydrogenases, oxidases, and in multi‑subunit enzymes that
The domain has been catalogued in protein family databases such as Pfam (PFxxxx) and InterPro, where it