MultiTargetScreening
MultiTargetScreening is a strategy in drug discovery and pharmacology that evaluates chemical compounds against multiple biological targets in a coordinated fashion. It aims to map activity profiles across a panel of targets rather than pursuing a single supposed receptor or enzyme, enabling exploration of polypharmacology and selectivity.
The rationale rests on the observation that many diseases involve networks of interacting proteins and pathways.
Methods include experimental and computational approaches. Experimentally, multiplexed or parallel screens test compounds against a curated
Workflow typically starts with defining a target panel aligned to a therapeutic goal, assembling a diverse
Applications include early discovery for complex diseases such as cancer or neurodegenerative disorders, as well as
Challenges involve managing large, heterogeneous data, addressing assay compatibility, controlling false positives, and achieving a meaningful
See also polypharmacology, multi-target drugs, high-throughput screening, chemogenomics.