MtrA
MtrA is a response regulator protein that functions as part of the MtrAB two-component regulatory system in actinobacteria, most notably in Mycobacterium tuberculosis and related species. It belongs to the common family of response regulators that receive a phosphate group on a conserved aspartate residue in their N-terminal receiver domain and use a C-terminal DNA-binding domain to regulate transcription.
In the canonical signaling pathway, the sensor kinase MtrB autophosphorylates in response to cellular or environmental
Biological function and importance are centered on cell cycle and cell envelope biology. The MtrAB system is
Regulation and targets of MtrA are context-dependent, with its activity modulated by phosphorylation state and growth
Clinical and research relevance: due to its essential role and central position in a key regulatory network,