Mfs1

Mfs1 is a gene symbol used in molecular biology to denote a member of the major facilitator superfamily (MFS) of transporters. The designation appears in multiple organisms, especially fungi and bacteria, where Mfs1-related proteins function as membrane transporters that move small solutes across the cell membrane. Members of the MFS are typically around 500 amino acids in length and contain 12 transmembrane α-helices, forming a central channel through which substrates can pass.

Substrate specificity among Mfs1 homologs varies widely. Some Mfs1-like transporters are involved in nutrient uptake, transporting sugars, amino acids, or other organic compounds. Others may participate in the efflux of xenobiotics or drugs under stress conditions, contributing to cellular defense and adaptation. The exact physiological role of a given Mfs1 protein depends on its sequence, regulatory context, and cellular localization.

Nomenclature for Mfs1 follows species-specific conventions, and the same symbol can refer to different, non-orthologous genes in different organisms. Therefore, researchers often verify the organism and gene model when comparing Mfs1 proteins across studies. Related topics include the major facilitator superfamily, transporter proteins, and membrane biology.