MLL14

MLL14 is not a recognized gene symbol in major biological databases. As of 2024, HGNC, Ensembl, and NCBI Gene do not list an official MLL14 symbol, and there is no peer-reviewed protein named MLL14. The term is typically regarded as ambiguous or a potential misnomer.

In contrast, the MLL family of histone methyltransferases includes MLL1 (KMT2A), MLL2 (KMT2D), MLL3 (KMT2C), and MLL4 (KMT2B). These enzymes catalyze methylation of histone H3 on lysine 4 (H3K4) and are involved in transcriptional activation and chromatin regulation. They participate in COMPASS-like multiprotein complexes and play roles in development, hematopoiesis, and oncogenesis. Rearrangements of MLL1, in particular, are well known in acute leukemias.

If MLL14 appears in a document, it is likely a typographical error, an internal code, or a species- or project-specific designation rather than an established gene symbol. To resolve the intent, consult the original source or check authoritative gene nomenclature databases.

See also: MLL1, MLL2, MLL3, MLL4, histone methyltransferase, epigenetics.