MLL

Mll denotes several distinct terms across disciplines. The capitalization MLL is common, with lowercase 'mll' appearing in certain contexts. This article outlines two widely recognized uses: a human gene involved in leukemia and a professional lacrosse league in North America.

MLL gene, also called mixed-lineage leukemia gene, or KMT2A, encodes a histone methyltransferase that regulates gene expression via histone methylation. It resides on chromosome 11q23. Rearrangements of MLL with various partner genes produce fusion proteins that drive leukemogenesis, notably in infant, pediatric, and some adult leukemias. Prognosis depends on age, cytogenetics, and specific fusion partner; treatment typically involves chemotherapy, and may include targeted therapy and stem cell transplantation.

Major League Lacrosse (MLL) was a professional field lacrosse league in the United States and Canada. Founded in 2001, it operated seasons featuring teams competing for the league championship. In 2020, MLL merged with the Premier Lacrosse League, and the MLL brand ceased operations as teams joined the PLL.