MAPKPI3

MAPKPI3, also known as Mitogen-activated protein kinase kinase kinase 3, is a protein that plays a crucial role in cellular signaling pathways. It is a member of the MAPKKK family, which includes enzymes that activate MAPKKs (mitogen-activated protein kinase kinases), ultimately leading to the activation of MAPKs (mitogen-activated protein kinases). MAPKPI3 is involved in various biological processes, including cell proliferation, differentiation, and survival. Its activation is often triggered by extracellular stimuli, such as growth factors, cytokines, or stress signals. MAPKPI3 is encoded by the MAP3K3 gene, which is located on chromosome 17q23.3 in humans. Mutations in the MAP3K3 gene have been associated with several diseases, including cancer and inflammatory disorders. The protein is composed of 454 amino acids and has a molecular weight of approximately 50 kDa. MAPKPI3 is a homodimer, and its activation involves phosphorylation by upstream kinases. The activated MAPKPI3 then phosphorylates and activates MAPKKs, which in turn activate MAPKs. This cascade of phosphorylation events is essential for the transmission of extracellular signals to the nucleus, where they can regulate gene expression and cellular responses.