Lescol

Lescol is the brand name for fluvastatin, a statin medication used to lower low-density lipoprotein (LDL) cholesterol and reduce cardiovascular risk in adults with hyperlipidemia or established risk factors. It is available in two formulations: immediate-release tablets (20 mg and 40 mg) and an extended-release capsule (Lescol XL, 80 mg). Typical starting dose is 20 mg once daily in the evening, with adjustments up to 40 mg after about four weeks and a maximum of 80 mg daily, depending on formulation and tolerance.

Fluvastatin lowers cholesterol by inhibiting HMG-CoA reductase, the key enzyme in hepatic cholesterol synthesis. This leads to reduced intrahepatic cholesterol and upregulation of LDL receptors, resulting in lower circulating LDL cholesterol. The drug can also cause modest changes in triglycerides and HDL cholesterol.

Pharmacokinetically, fluvastatin is primarily metabolized in the liver by the CYP2C9 system and is predominantly excreted in bile. The extended-release formulation supports once-daily dosing. While generally well tolerated, fluvastatin can interact with other medications and, like other statins, carries a risk of myopathy and rhabdomyolysis, especially at higher doses or with interacting drugs.

Common adverse effects include headache, nausea, abdominal pain, and dizziness. Serious but rare risks include muscle injury and liver enzyme elevations. Contraindications include active liver disease and pregnancy or breastfeeding. Caution is advised in liver or kidney impairment and with substantial alcohol use. Baseline liver function tests and periodic monitoring, along with lipid panels after 4–12 weeks, are recommended to assess response and safety.