Leberzellcords

Leberzellcords are a type of biological scaffold composed of extracellular matrix derived from porcine liver cells. The term combines the German word “Leberzell” (liver cell) with “cords,” indicating the structural format of the scaffold. The material is produced by decellularizing porcine hepatic tissue and then shaping the remaining matrix into fibrous cord-like constructs. This process preserves the native extracellular proteins, growth factors, and basement membrane components, which are believed to support cellular adhesion and proliferation.

In regenerative medicine research, Leberzellcords have been investigated as a delivery platform for liver progenitor cells. Laboratory studies have shown that the scaffold promotes hepatocyte differentiation and enhances vascularization in vitro. In animal models, implantation of these cords has led to improved hepatic function and accelerated tissue repair following partial hepatectomy. Early-stage clinical trials have explored their safety and potential therapeutic benefit in patients with acute liver failure, though results are preliminary and limited in sample size.

The product is manufactured in compliance with European and United States regulatory standards for xenogeneic tissues. Quality control tests include assessment of residual DNA, sterility, endotoxin levels, and mechanical integrity. Although marketed primarily for research purposes, there is growing interest in broader clinical applications such as bioartificial liver devices and cell transplantation strategies.

Critical evaluation of the literature highlights both promising regenerative outcomes and concerns regarding immunogenicity and long‑term integration. Comparative studies with other liver-derived scaffolds, such as decellularized full-thickness liver matrices, suggest that Leberzellcords offer a simpler, more scalable alternative, though further long-term data are required to establish efficacy and safety in human therapy.