Leberersatzverfahren

Leberersatzverfahren refers to a group of medical procedures and technologies aimed at replacing the function of a failing or diseased liver. These methods are employed when a liver transplant is not immediately available or is not a suitable option for a patient. The primary goal of these techniques is to support the patient's body by performing the essential functions of the liver, such as detoxification, protein synthesis, and bile production, until the native liver recovers or a transplant can be performed.

One of the most established Leberersatzverfahren is the use of liver dialysis, also known as molecular adsorbent recirculation system (MARS). MARS uses artificial membranes to filter the blood, removing toxins that the liver can no longer process. This system can temporarily alleviate the effects of liver failure. Another approach involves bioartificial liver devices (BALs). These devices typically contain living liver cells, either from animals or humans, encapsulated within a bioreactor. Blood is passed through the bioreactor, where the cells perform metabolic functions, essentially acting as an external liver.

More advanced research is exploring regenerative medicine and stem cell therapies as potential Leberersatzverfahren. The idea is to use stem cells to either regenerate damaged liver tissue or to grow functional liver tissue in a laboratory setting that can then be implanted. While still largely experimental, these approaches hold promise for more permanent solutions to liver failure. The development of Leberersatzverfahren is crucial for improving outcomes for patients with acute and chronic liver diseases, providing a vital bridge to recovery or transplantation.